Management of agitation and sedation in Critical Units. Any news?
DOI:
https://doi.org/10.30445/rear.v11i11.798Keywords:
critical units, critical patient, sedation, agitationAbstract
We conducted a review of the clinical practice guide for the prevention and management of agitation and sedation in patients admitted to critical units. It is a guide that includes recommendations on five critical patient sections: pain, agitation / sedation, delirium, immobility (mobilization / rehabilitation) and sleep (disruption). We analyzed the recommendations established for the optimal level of sedation, the evaluation and interruption of sedation, the correct choice of sedative and the accompaniment of physical restraint measures.
This guide has been developed by a group of 32 international experts, 4 methodology specialists and 4 critically ill survivors gathered to update and expand the clinical practice guidelines of 2013.
A great agreement was obtained between the opinion of these international experts of the disciplinary differences together with the review of the literature of five electronic databases from 1990 to 2015 to support these recommendations with the highest level of evidence based on the GRADE methodology.
They presented the recommendations with a level of evidence "high", "moderate" or "low", supported and discussed in plenary sessions, approving those that exceeded 80% of the consensus. Among the results obtained, 37 recommendations were issued (3 of high evidence and 34 moderate). The need to improve research on pain, agitation / sedation, delirium, immobility (mobilization / rehabilitation) and sleep (disruption) that provide the basis for the improvement of results in this vulnerable population was highlighted.
References
- Shehabi Y, Bellomo R, Reade MC, et al; Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators; ANZICS Clinical Trials Group: Early intensive care sedation predicts longterm mortality in ventilated critically ill patients. Am J Respir Crit Care Med 2012; 186:724–731
- Mehta S, Burry L, Cook D, et al; SLEAP Investigators; Canadian Critical Care Trials Group: Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: A randomized controlled trial. JAMA 2012; 308:1985–1992
- Oliver WC Jr, Nuttall GA, Murari T, et al: A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia after cardiac surgery. J Cardiothorac Vasc Anesth 2011; 25:110–119
- Zhou Y, Jin X, Kang Y, et al: Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: A prospective, randomized study. Crit Care 2014; 18:R122
- Riker RR, Shehabi Y, Bokesch PM, et al; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group: Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial. JAMA 2009; 301:489–499
- Jakob SM, Ruokonen E, Grounds RM, et al;MIDEX Dexmedetomidine for Long-Term Sedation Investigators: Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: Two randomized controlled trials. JAMA 2012; 307:1151–1160
- MacLaren R, Preslaski CR, Mueller SW, et al: A randomized, doubleblind pilot study of dexmedetomidine versus midazolam for intensive care unit sedation: Patient recall of their experiences and short-term psychological outcomes. J Intensive Care Med 2015; 30:167–175
- Trouiller P, Fangio P, Paugam-Burtz C, et al: Frequency and clinical impact of preserved bispectral index activity during deep sedation in mechanically ventilated ICU patients. Intensive Care Med 2009; 35:2096–2104
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