Efficacy and safety of epidural morphic chloride in laparoscopic abdominal surgery. Observational study.

Authors

  • Alberto Fuentes Medical Specialist in Anesthesiology and Resuscitation. Anesthesiology and Resuscitation Service. Terrassa Hospital. CST. (Barcelona). Spain
  • Mamen Carmona Doctor in Biology. R+D+I, Project Manager. Research Area & Innovation. Terrassa Hospital. CST. (Barcelona). Spain
  • Daniel Florescu Medical Specialist in Anesthesiology and Resuscitation. Anesthesiology and Resuscitation Service. Terrassa Hospital. CST. (Barcelona). Spain
  • José Antonio Bernia Head of Service. Anesthesiology and Resuscitation Service. Terrassa Hospital. CST. (Barcelona). Spain

DOI:

https://doi.org/10.30445/rear.v15i8.1147

Keywords:

analgesia, epidural , chloride, morphine , laparoscopic surgical procedure , anesthesia, epidural

Abstract

The use of epidural neuraxial morphine for abdominal surgery is widely described in the medical literature. Its use has sometimes been limited by the possible appearance of adverse effects, emphasizing among them, respiratory depression. In abdominal laparoscopic surgery and specifically in enhanced recovery programs (P.R.I.) its use is limited by the possible appearance of side effects that can basically lengthen the length of stay (L.O.S.), from the acronym in English . Its use is limited to the results obtained and the consensus reached with the different members of the P.R.I. internally, of the institution. That is why, in order to know and evaluate the results obtained, we carried out an internal audit (self audit), retrospectively collecting the different variables of interest in the use of epidural morphine in laparoscopic major abdominal surgery, in the periods between 14-1-2016 and 11-10-2020 and in transperitoneal laparoscopic nephrectomy surgeries between 11-9-2015 and 06-30-2017. We want to share and publicize the results of this study, focused on analgesic efficacy and clinical safety

References

- Bujedo BM. Spinal opioid bioavailability in postoperative pain. Pain Pract. 2014 Apr;14(4):350-64. doi: 10.1111/papr.12099. Epub 2013 Jul 8. PMID: 23834413

- Mugabure Bujedo B. A clinical approach to neuraxial morphine for the treatment of postoperative pain. Pain Res Treat. 2012;2012:612145. doi: 10.1155/2012/612145. Epub 2012 Jul 2. PMID: 23002426; PMCID: PMC3395154

- Sharawi N, Carvalho B, Habib AS, Blake L, Mhyre JM, Sultan P. A Systematic Review Evaluating Neuraxial Morphine and Diamorphine-Associated Respiratory Depression After Cesarean Delivery. Anesth Analg. 2018 Dec;127(6):1385-1395. doi: 10.1213/ANE.0000000000003636. PMID: 30004934.

- Venara A, Neunlist M, Slim K, Barbieux J, Colas PA, Hamy A, Meurette G. Postoperative ileus: Pathophysiology, incidence, and prevention. J Visc Surg. 2016 Dec;153(6):439-446. doi: 10.1016/j.jviscsurg.2016.08.010. Epub 2016 Sep 23. PMID: 27666979.

- Carli F, Kehlet H, Baldini G, Steel A, McRae K, Slinger P, Hemmerling T, Salinas F, Neal JM. Evidence basis for regional anesthesia in multidisciplinary fast-track surgical care pathways. Reg Anesth Pain Med. 2011 Jan-Feb;36(1):63-72. doi: 10.1097/AAP.0b013e31820307f7. PMID: 22002193.

- Stenseth R, Sellevold O, Breivik H. Epidural morphine for postoperative pain: experience with 1085 patients. Acta Anaesthesiol Scand. 1985 Jan;29(1):148-56. doi: 10.1111/j.1399-6576.1985.tb02176.x. PMID: 3976321.

- Roofthooft E, Joshi GP, Rawal N, Van de Velde M; PROSPECT Working Group* of the European Society of Regional Anaesthesia and Pain Therapy and supported by the Obstetric Anaesthetists’ Association. PROSPECT guideline for elective caesarean section: updated systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia. 2021 May;76(5):665-680. doi: 10.1111/anae.15339. Epub 2020 Dec 28. PMID: 33370462; PMCID: PMC8048441.

- Ochi G, Yamane C, Arai T. Optimum dose of epidural morphine for postsurgical analgesia. J Anesth. 1990 Jan;4(1):35-9. doi: 10.1007/s0054000040035. PMID: 15236014.

- Rawal N. Epidural analgesia for postoperative pain: Improving outcomes or adding risks? Best Pract Res Clin Anaesthesiol. 2021 May;35(1):53-65. doi: 10.1016/j.bpa.2020.12.001. Epub 2020 Dec 5. PMID: 33742578

Published

2023-09-05

How to Cite

Fuentes, A., Carmona, M., Florescu, D., & Bernia, J. A. (2023). Efficacy and safety of epidural morphic chloride in laparoscopic abdominal surgery. Observational study. Revista Electrónica AnestesiaR, 15(8). https://doi.org/10.30445/rear.v15i8.1147

Issue

Section

Original research articles