Take off your blinders. Fragility of statistical significance.

Authors

  • Manuel Molina Gastroenterology Service, Hospital Infantil Universitario La Paz, Madrid. Spain

DOI:

https://doi.org/10.30445/rear.v13i8.977

Keywords:

fragility index, statistical significance, clinical relevance

Abstract

Fragililty index represents the number of outcomes in a trial that should change to reverse, or achieve, statistical significance. This index should also take into account the probability of that changes to occurr and the clinical relevance of the results.

Author Biography

Manuel Molina, Gastroenterology Service, Hospital Infantil Universitario La Paz, Madrid. Spain

Especialista en Pediatrí­a y sus áreas Especí­ficas desde 1991. Actualmente ejerzo en el Servicio de Gastroenterologí­a del Hospital Infantil Universitario La Paz, de Madrid.
Además, pertenezco al Grupo de Trabajo de Pediatrí­a Basada en la Evidencia, grupo compartido entre la Asociación Española de Pediatrí­a y la Asociación Española de Pediatrí­a de Atención Primaria.

References

- Walter SD, Thabane L, Briel M. The fragility of trial results involves more tha statistical significance alone. J Clin Epidemiol.2020;124:34-41.

- Feinstein AR. The unit fragility index: an additional appraisal of “statistical significance” for a contrast of two porportions. J Clin Epidemio.1990;43:201-9.

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Published

2021-09-06

How to Cite

Molina, M. (2021). Take off your blinders. Fragility of statistical significance. Revista Electrónica AnestesiaR, 13(8). https://doi.org/10.30445/rear.v13i8.977

Issue

Vol. 13 No. 8 (2021): Revista Electrónica de AnestesiaR

Section

Original

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Copyright (c) 2021 Revista Electrónica AnestesiaR

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