Anestesia en la Cirugía Citorreductora y la Quimioterapia hipertérmica intraperitoneal (HIPEC)
DOI:
https://doi.org/10.30445/rear.v6i6.232Palabras clave:
HIPEC, Peritoneal CarcinomatosisResumen
La consideración del peritoneo como un órgano, similar al hígado o al pulmón, y el tratamiento de las metástasis peritoneales (MP) con una cirugía citorreductora (CCR) óptima unida a la perfusión intraperitoneal de una solución hipertérmica del citostático adecuado, ha modificado radicalmente las opciones terapéuticas de los pacientes con carcinomatosis peritoneal (CP).
Hoy en día la combinación de CCR completa e HIPEC (hyperthermic intraoperative peritoneal chemotherapy) es el tratamiento estándar del pseudomixoma y los mesoteliomas peritoneales, así como de la CP de origen colorectal. La HIPEC está en fase de evaluación, con resultados prometedores en el cáncer de ovario, en el gástrico y en la CP secundaria a tumores neuroendocrinos. Se ha iniciado además otra nueva línea terapéutica basada en el concepto de “carcinoprofilaxis”, con la realización de un “second-look” en pacientes tipificados de alto riesgo de desarrollar una CP.
La supervivencia media de la CP de origen colorectal no es superior a los 18 meses, con los nuevos agentes citostáticos vía endovenosa. La combinación de CCR óptima + HIPEC, en pacientes seleccionados, ofrece una supervivencia media de 60 meses y una supervivencia a los 5 años entre un 32% y un 48%.
Citas
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4.- Mohamed F, Moran BJ. Morbidity and mortality with cytoreductive surgery and intraperitoneal chemotherapy: the importance of a learning curve. Cancer J. 2009 May-Jun;15(3):196-9.
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6.- Jafari MD, Halabi WJ, Stamos MJ, Nguyen VQ, Carmichael JC, Mills SD, Pigazzi A. Surgical Outcomes of Hyperthermic Intraperitoneal Chemotherapy: Analysis of the American College of Surgeons National Surgical Quality Improvement Program. JAMA Surg. 2013 Dec 18.
7.- Pérez J, Rodríguez MJ, Campaña O, Veiras S, Lorenzo D, Lamas M, Alvarez J. Anesthetic management for scheduled peritonectomy and hyperthermic intraperitoneal chemotherapy in 20 patients. Rev Esp Anestesiol Reanim. 2006 Nov;53(9):550-5.
8.- López-Berlanga JL, De Miguel A, Elvira A. Anesthesia and postoperative care of 11 patients undergoing peritonectomy and hypothermic intraperitoneal chemotherapy. Rev Esp Anestesiol Reanim. 2004 Oct;51(8):423-8.
9.- Raspe C, Piso P, Wiesenack C, Bucher M. Anesthetic management in patients undergoing hyperthermic chemotherapy. Curr Opin Anaesthesiol. 2012 Jun;25(3):348-55.
10.- Webb CA, Weyker PD, Moitra VK, Raker RK. An overview of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for the anesthesiologist. Anesth Analg. 2013 Apr;116(4):924-31.
11.- Rothfield KP, Crowley K. Anesthesia considerations during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Surg Oncol Clin N Am. 2012 Oct;21(4):533-41.
12.- Schmidt C, Moritz S, Rath S, Grossmann E, Wiesenack C, Piso P, Graf BM, Bucher M. Perioperative management of patients with cytoreductive surgery for peritoneal carcinomatosis. J Surg Oncol. 2009 Sep 15;100(4):297-301.
13.- Bell JC, Rylah BG, Chambers RW, Peet H, Mohamed F, Moran BJ. Perioperative management of patients undergoing cytoreductive surgery combined with heated intraperitoneal chemotherapy for peritoneal surface malignancy: a multi-institutional experience. Ann Surg Oncol. 2012 Dec;19(13):4244-51.
14.- Thanigaimani K, Mohamed F, Cecil T, Moran BJ, Bell J. The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy. Colorectal Dis. 2013 Dec;15(12):1537-42.
15.- De Somer F, Ceelen W, Delanghe J, De Smet D, Vanackere M, Pattyn P, Mortier E. Severe hyponatremia, hyperglycemia, and hyperlactatemia are associated with intraoperative hyperthermic intraperitoneal chemoperfusion with oxaliplatin. Perit Dial Int. 2008 Jan-Feb;28(1):61-6.
16.- Raue W, Tsilimparis N, Langelotz C, Rau B, Schwenk W, Hartmann J. Initial results after implementation of a multimodal treatment for peritoneal malignancies. Acta Chir Belg. 2011 Mar-Apr;111(2):68-72.
17.- Desgranges FP, Steghens A, Rosay H, Méeus P, Stoian A, Daunizeau AL, Pouderoux-Martin S, Piriou V. Epidural analgesia for surgical treatment of peritoneal carcinomatosis: a risky technique? Ann Fr Anesth Reanim. 2012 Jan;31(1):53-9.
18.- Cooksley TJ, Haji-Michael P. World. Post-operative critical care management of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy. J Surg Oncol. 2011 Dec 19;9:169.
19.- Thanigaimani K, Mohamed F, Cecil T, Moran BJ, Bell J. The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy. Thanigaimani K, Mohamed F, Cecil T, Moran BJ, Bell J. Colorectal Dis. 2013 Dec;15(12):1537-42.
20.- Glockzin G, von Breitenbuch P, Schlitt HJ, Piso P. J. Treatment-related morbidity and toxicity of CRS and oxaliplatin-based HIPEC compared to a mitomycin and doxorubicin-based HIPEC protocol in patients with peritoneal carcinomatosis: a matched-pair analysis. Surg Oncol. 2013 May;107(6):574-8.
21.- Arakelian E, Torkzad MR, Bergman A, Rubertsson S, Mahteme H. Pulmonary influences on early post-operative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment: a retrospective study. Arakelian E, Torkzad MR, Bergman A, Rubertsson S, Mahteme H. World J Surg Oncol. 2012 Nov 27; 10:258.
22.- Cooksley TJ, Haji-Michael P. Post-operative critical care management of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy. World J Surg Oncol. 2011 Dec 19;9:169.
23.- Cascales PA, Gil J, Galindo PJ, Machado F, Frutos IM, Paricio PP. Heterogeneity in patients and methods. A problem for hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):361-2.
2.- Sugarbaker PH. Early intervention for treatment and prevention of colorectal carcinomatosis: a plan for individualized care. Surg Oncol Clin N Am. 2012 Oct;21(4):689-703.
3.- Elias D, Lefevre JH, Chevalier J, Brouquet A, Marchal F, Classe JM, et al. Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin. J Clin Oncol 2009;27:681–5.
4.- Mohamed F, Moran BJ. Morbidity and mortality with cytoreductive surgery and intraperitoneal chemotherapy: the importance of a learning curve. Cancer J. 2009 May-Jun;15(3):196-9.
5.-Kuijpers AM, Mirck B, Aalbers AG, Nienhuijs SW, de Hingh IH, Wiezer MJ, van Ramshorst B, van Ginkel RJ, Havenga K, Bremers AJ, de Wilt JH, Te Velde EA, Verwaal VJ. Cytoreduction and HIPEC in the Netherlands: nationwide long-term outcome following the Dutch protocol. Ann Surg Oncol. 2013 Dec;20(13):4224-30.
6.- Jafari MD, Halabi WJ, Stamos MJ, Nguyen VQ, Carmichael JC, Mills SD, Pigazzi A. Surgical Outcomes of Hyperthermic Intraperitoneal Chemotherapy: Analysis of the American College of Surgeons National Surgical Quality Improvement Program. JAMA Surg. 2013 Dec 18.
7.- Pérez J, Rodríguez MJ, Campaña O, Veiras S, Lorenzo D, Lamas M, Alvarez J. Anesthetic management for scheduled peritonectomy and hyperthermic intraperitoneal chemotherapy in 20 patients. Rev Esp Anestesiol Reanim. 2006 Nov;53(9):550-5.
8.- López-Berlanga JL, De Miguel A, Elvira A. Anesthesia and postoperative care of 11 patients undergoing peritonectomy and hypothermic intraperitoneal chemotherapy. Rev Esp Anestesiol Reanim. 2004 Oct;51(8):423-8.
9.- Raspe C, Piso P, Wiesenack C, Bucher M. Anesthetic management in patients undergoing hyperthermic chemotherapy. Curr Opin Anaesthesiol. 2012 Jun;25(3):348-55.
10.- Webb CA, Weyker PD, Moitra VK, Raker RK. An overview of cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion for the anesthesiologist. Anesth Analg. 2013 Apr;116(4):924-31.
11.- Rothfield KP, Crowley K. Anesthesia considerations during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Surg Oncol Clin N Am. 2012 Oct;21(4):533-41.
12.- Schmidt C, Moritz S, Rath S, Grossmann E, Wiesenack C, Piso P, Graf BM, Bucher M. Perioperative management of patients with cytoreductive surgery for peritoneal carcinomatosis. J Surg Oncol. 2009 Sep 15;100(4):297-301.
13.- Bell JC, Rylah BG, Chambers RW, Peet H, Mohamed F, Moran BJ. Perioperative management of patients undergoing cytoreductive surgery combined with heated intraperitoneal chemotherapy for peritoneal surface malignancy: a multi-institutional experience. Ann Surg Oncol. 2012 Dec;19(13):4244-51.
14.- Thanigaimani K, Mohamed F, Cecil T, Moran BJ, Bell J. The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy. Colorectal Dis. 2013 Dec;15(12):1537-42.
15.- De Somer F, Ceelen W, Delanghe J, De Smet D, Vanackere M, Pattyn P, Mortier E. Severe hyponatremia, hyperglycemia, and hyperlactatemia are associated with intraoperative hyperthermic intraperitoneal chemoperfusion with oxaliplatin. Perit Dial Int. 2008 Jan-Feb;28(1):61-6.
16.- Raue W, Tsilimparis N, Langelotz C, Rau B, Schwenk W, Hartmann J. Initial results after implementation of a multimodal treatment for peritoneal malignancies. Acta Chir Belg. 2011 Mar-Apr;111(2):68-72.
17.- Desgranges FP, Steghens A, Rosay H, Méeus P, Stoian A, Daunizeau AL, Pouderoux-Martin S, Piriou V. Epidural analgesia for surgical treatment of peritoneal carcinomatosis: a risky technique? Ann Fr Anesth Reanim. 2012 Jan;31(1):53-9.
18.- Cooksley TJ, Haji-Michael P. World. Post-operative critical care management of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy. J Surg Oncol. 2011 Dec 19;9:169.
19.- Thanigaimani K, Mohamed F, Cecil T, Moran BJ, Bell J. The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy. Thanigaimani K, Mohamed F, Cecil T, Moran BJ, Bell J. Colorectal Dis. 2013 Dec;15(12):1537-42.
20.- Glockzin G, von Breitenbuch P, Schlitt HJ, Piso P. J. Treatment-related morbidity and toxicity of CRS and oxaliplatin-based HIPEC compared to a mitomycin and doxorubicin-based HIPEC protocol in patients with peritoneal carcinomatosis: a matched-pair analysis. Surg Oncol. 2013 May;107(6):574-8.
21.- Arakelian E, Torkzad MR, Bergman A, Rubertsson S, Mahteme H. Pulmonary influences on early post-operative recovery in patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy treatment: a retrospective study. Arakelian E, Torkzad MR, Bergman A, Rubertsson S, Mahteme H. World J Surg Oncol. 2012 Nov 27; 10:258.
22.- Cooksley TJ, Haji-Michael P. Post-operative critical care management of patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy. World J Surg Oncol. 2011 Dec 19;9:169.
23.- Cascales PA, Gil J, Galindo PJ, Machado F, Frutos IM, Paricio PP. Heterogeneity in patients and methods. A problem for hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):361-2.
Publicado
2014-06-30
Cómo citar
Mora Fernández, C., Ferrer Robles, ana, Gómez Romero, G., Melero Larrocha, C., & Verd Rodríguez, M. (2014). Anestesia en la Cirugía Citorreductora y la Quimioterapia hipertérmica intraperitoneal (HIPEC). Revista Electrónica AnestesiaR, 6(6), 3. https://doi.org/10.30445/rear.v6i6.232
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