Is the Marik protocol effective in septic shock?
DOI:
https://doi.org/10.30445/rear.v13i2.906Keywords:
shock séptico, libre de vasopresor, hidrocortisona, vitamina C, tiamina, septic shock, free of vasopressor, hydrocortisone, vitamin C, thiamineAbstract
In recent years, numerous attempts have been made to reduce the mortality associated with septic shock, both from the point of view of early diagnosis and treatment optimization. New developments in the treatment include the use of vitamin C and thiamine associated with hydrocortisone, with several observational studies having been shown to improve survival and decrease in vasopressor use. However, this new clinical trial calls into question the role of vitamin C and thiamine, without finding significant differences between hydrocortisone monotherapy and the combination of all three.
References
- Fowler A et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014; 12:3
- Donnino MW et al. Thiamine deficiency in critically ill patients with sepsis. J Crit Care 2010; 25(4): 576-81.
- Woolum JA et al. Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Crit Care Med 2018; 46(11): 1747-52.
- Marik P, Khangoora V, Rivera R, Hooper M, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151(6):1229-1238.
- Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.
- Fowler A, Truwit J, Hite R, et al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019;322(13):1261-1270.
- Carr AC. Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C? Crit Care. 2020 Apr 6;24(1):129. doi: 10.1186/s13054-020-02853-2. PMID: 32252799; PMCID: PMC7137516.
- Consoli DC, Jesse JJ, Klimo KR, Tienda AA, Putz ND, Bastarache JA, Harrison FE. A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain. Nutrients. 2020 Mar 26;12(4):911. doi: 10.3390/nu12040911. PMID: 32224930; PMCID: PMC7231213.
- Honore PM, Spapen HD, Marik P, Boer W, Oudemans-van Straaten H. Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review. Ann Intensive Care. 2020 Feb 12;10(1):23. doi: 10.1186/s13613-020-0640-6. PMID: 32052229; PMCID: PMC7016079.
- Donnino MW et al. Thiamine deficiency in critically ill patients with sepsis. J Crit Care 2010; 25(4): 576-81.
- Woolum JA et al. Effect of thiamine administration on lactate clearance and mortality in patients with septic shock. Crit Care Med 2018; 46(11): 1747-52.
- Marik P, Khangoora V, Rivera R, Hooper M, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151(6):1229-1238.
- Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801-10.
- Fowler A, Truwit J, Hite R, et al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019;322(13):1261-1270.
- Carr AC. Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C? Crit Care. 2020 Apr 6;24(1):129. doi: 10.1186/s13054-020-02853-2. PMID: 32252799; PMCID: PMC7137516.
- Consoli DC, Jesse JJ, Klimo KR, Tienda AA, Putz ND, Bastarache JA, Harrison FE. A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain. Nutrients. 2020 Mar 26;12(4):911. doi: 10.3390/nu12040911. PMID: 32224930; PMCID: PMC7231213.
- Honore PM, Spapen HD, Marik P, Boer W, Oudemans-van Straaten H. Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review. Ann Intensive Care. 2020 Feb 12;10(1):23. doi: 10.1186/s13613-020-0640-6. PMID: 32052229; PMCID: PMC7016079.
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Published
2021-03-03
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Armelles Bello, E., & García Álvarez, R. (2021). Is the Marik protocol effective in septic shock?. Revista Electrónica AnestesiaR, 13(2). https://doi.org/10.30445/rear.v13i2.906
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