Evidence in critical ill adults management with COVID-19

Abstract

The emerging acute respiratory Coronavirus Disease syndrome (COVID-19) Working Group Guides of the Surviving Sepsis Campaign (SSC) guidelines for critical patients (a panel of 36 experts from 12 countries), were reviewed by using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to classify bibliographic evidence as high, moderate, low or very low. They generated recommendations based on the balance between benefit and harm, resource and cost implications, equity and feasibility. Recommendations were either strong or weak or in the form of best practice recommendations. 54 statements advising to control infection, resuscitation and hemodynamic management, respiratory management and specific treatment were studied. Recommendations were either strong (9) or weak (35), or in the form of best practice recommendations (4), and others were discouraged (6).