Optimization strategies for the use of beta -lactams.

The importance of the pathophysiological peculiarities in the critically ill patient.

Authors

  • Luisa Maria Charco Roca Facultativo Especialista de área. Servicio de Anestesiología y Reanimación, Hospital General Universitario de Albacete. http://orcid.org/0000-0002-8340-8516
  • José María Jiménez Vizuete Jefe de Sección. Servicio de Anestesiología y Reanimación, Hospital General Universitario de Albacete.
  • Antonio Ayelo Navarro Jefe de Servicio, Hospital General de Almansa, Albacete.

DOI:

https://doi.org/10.30445/rear.v11i9.786

Keywords:

pharmacodynamics, pharmacokinetics, sepsis or septic shock, antibiotics, Critical care or intensive care

Abstract

There are several  strategies aimed at improving the use of antibiotics in critical patients. These strategies include de-escalation, cycling, early treatment or the use of pharmacokinetic / pharmacodynamic parameters to adjust the dosage. The pathophysiological changes that occur in the critical patient can condition the pharmacokinetics and pharmacodynamics paramethers of antibiotics, especially in beta-lactams. Therefore, anticipating the antimicrobial result based on their plasma concentrations in the place of action can be very difficult to establish, which, in turn, may have clinically relevant consequences. The pharmacodynamic profile of beta-lactams can be improved, through longer exposure with more frequent doses or with continuous or extended infusions, especially to treat multiresistant bacteria.

References

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Published

2020-08-13

How to Cite

Charco Roca, L. M., Jiménez Vizuete, J. M., & Ayelo Navarro, A. (2020). Optimization strategies for the use of beta -lactams.: The importance of the pathophysiological peculiarities in the critically ill patient. Revista Electrónica AnestesiaR, 11(9), 3. https://doi.org/10.30445/rear.v11i9.786

Issue

Vol. 11 No. 9 (2019): Revista Electrónica de AnestesiaR

Section

Review articles

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Copyright (c) 2019 Revista Electrónica AnestesiaR

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