Ketamine and its indication in acute postoperative pain
DOI:
https://doi.org/10.30445/rear.v10i4.680Keywords:
general anesthesia, acute pain, pain, ketamineAbstract
Ketamine was first synthesized in 1962 by Calvin Stevens at Parke-Davis Co as an alternative anesthetic to phencyclidine. It was first used in humans in 1965 by Corssen and Domino under the name "Ketalar". It was about 20 inmates who volunteered. In 1970 it was introduced into the hospital clinic and soon after it was widely administered to American soldiers during the Vietnam War. It was described as a "unique drug" for being able to produce hypnosis, analgesia and amnesia. No other drug used in clinical practice produces these three important effects at the same time.
References
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4. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clin Pharmacokinet. 2016 Sep;55(9):1059-77
2. Gorlin A, Rosenfeld D, Ramakrishna H. Intravenous sub-anesthetic ketamine for perioperative analgesia. J Anaesthesiol Clin Pharmacol. 2016 Apr-Jun; 32(2): 160–167.
3. Kurdi MS, Theerth KA, Deva RS. Ketamine: Current applications in anesthesia, pain, and critical care. Anesth Essays Res. 2014 Sep-Dec;8(3):283-90.
4. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clin Pharmacokinet. 2016 Sep;55(9):1059-77
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Published
2020-09-10
How to Cite
Salazar Loaiza, K., & Abad - Torrent, A. (2020). Ketamine and its indication in acute postoperative pain. Revista Electrónica AnestesiaR, 10(4), 1. https://doi.org/10.30445/rear.v10i4.680
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