Fat overload syndrome after treatment of systemic poisoning by local anesthetics: A case report.
DOI:
https://doi.org/10.30445/rear.v15i6.1135Keywords:
Fat overload syndrome, lipid emulsion, local anaesthetic, systemic toxicity.Abstract
The use of lipid emulsions as antidotes for local anesthetic systemic toxicity (LAST) has increased in recent decades. Fat overload syndrome (FOS) is one of its complications
We report a case of a pregnant woman who received a 2% lidocaine bolus for caesarean section through an epidural catheter. Due to the suspicion of LAST because of neurological symptoms, she received a load of Intralipid®. In postoperative period, she debuted with jaundice, hyperthermia, tachycardia, and lactic acidosis. Once other complications were ruled out, FOS was suspected due to the presence of milky plasma. Treatment with fluid therapy and antipyretics was decided.
Although FOS is a rare complication, it should be suspected in patients who have received high doses of lipid emulsions. There are no studies on this syndrome in the obstetric population and there are different opinions regarding its treatment, although the central idea is fluid therapy to reduce plasma viscosity
References
- Liu Y, Zhang J, Yu P, Niu J, Yu S. Mechanisms and efficacy of intravenous lipid emulsion treatment for systemic toxicity from local anesthetics. Front Med (Lausanne). 2021 Nov 8;8:756866.
- Lodeserto F, Huang D. Accidental Bolus of Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition; 2015.
- Moon HJ, Hwang IW, Lee JW, Hong SY. American Journal of Emergency Medicine Case Report A case of fat overload syndrome after rapid infusion of SMOFlipid emulsion in an adult. 2021;35(2017):4–5.
- Levine M, Skolnik AB, Ruha A, Bosak A, Menke N, Pizon AF. Complications Following Antidotal Use of Intravenous Lipid Emulsion Therapy. Journal of Medical Toxicology; 2014;10–4.
- Hayes BD, Gosselin S, Calello DP, Nacca N, Rollins CJ, Abourbih D, et al; Lipid Emulsion Workgroup. Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration. Clin Toxicol (Phila). 2016;54(5):365-404.
- Errando CL, Freijo JJ, Vila M, Tardón L. Revista Española de Anestesiología y Reanimación. Rev Esp Anestesiol Reanim [Internet]. 2013;60(Supl 1):65–72. Available from: http://dx.doi.org/10.1016/S0034-9356(13)70011-2
- Mock ND, Griggs KM, Mileto LA. Local Anesthetic Systemic Toxicity during Labor, Birth and Immediate Postpartum: Clinical Review. MCN Am J Matern Child Nurs. 2021 Nov-Dec 01;46(6):330–8.
- Neal JM, Barrington MJ, Fettiplace MR, Gitman M, Memtsoudis SG, Mörwald EE, et al. REGIONAL ANESTHESIA AND ACUTE PAIN The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity Executive Summary 2017. 2018;43(2):113–23.
- El-boghdadly K, Pawa A, Chin KJ. Local anesthetic systemic toxicity : current perspectives. Journal of Local and Regional Anesthesia. 2018;35–44.
- Lauriti G, Zani A, Aufieri R, Cananzi M, Chiesa PL, Eaton S, et al. Incidence, Prevention and Treatment of Parenteral Nutrition-Associated Cholestasis and Intestinal Failure-Associated Liver Disease in Infants and Children; A Systematic Review. Journal of Parenteral and Enteral Nutrition. 2013
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