Propofol Infusion Syndrome, a perspective in Intensive Care Units

Abstract

Introduction. Propofol in one of the most widely used hypnotic for sugical procedures due to its rapid onset and reversal,currently wit great importance in critical care units for sedation given the possibility of tachyphylaxis in this type of patint. despide having and adequate safety profile, there is a direct relationship between high doses (>4mg/kg/hour) and prolonged (>48 hours) with propofol infusion syndrome, a rare and potentially fatal condition characterized primarily by acidosis metabolic, cardiovascular disorders, rhabdomyolysis and hyperkalemia. The incidence of this complication is around 1.1%. The objetive is to carry out a bibliographic review on the propofol infusion syndrome presenting the importance of the prevention, diagnosis and management of thie entity with its implications in intensive care units. Material and methods: Aliterature search was carried out in the PunMed and Scielo databases for updated and relevant articles in English of Spanish presenting the importance of prevention, diagnosis and pharmacological management. COnclusion: propofol infusion syndrome is a rare complication with high mortality, for which in-hospital strategies and protocols should be established for inmediate management in cases of suspicion or diagnosis in a timely manner.