Drug-induced nephrotoxicity in the perioperative period and ICU
DOI:
https://doi.org/10.30445/rear.v14i4.1007Keywords:
drugs, anesthetics, nephrotoxicityAbstract
Nephrotoxicity is defined as any kidney injury caused directly or indirectly by drugs, clinically depicted as acute renal failure, tubulopathy or glomerulopathy. Kidney damage can be preventable by knowing the drugs used in the perioperative period and intensive care unit. Pillars of nephrotoxic kidney damage management include reducing renal exposure to the toxic agent, correcting hydroelectrolytic disorders or hypovolemia, serum level determination, avoiding combinations of drugs from synergistically producing kidney damage, and trying to find therapeutic alternatives. This review aims to analyze alterations in renal function that can be caused by drugs used by anesthesiologists in their usual clinical practice. Thus, knowing these nephrotoxic drugs, the anesthesiologist will be able to detect early the renal impact of their administration and reduce the incidence of adverse effects. For the preparation of this review a bibliographic search was carried out in Pubmed and Medline with the following strategy: (Nephrotoxicity OR toxicity) AND (acute renal injury OR CRRT) AND (drugs OR anesthetics). Isolated clinical cases or articles not published in English or Spanish, as well as bibliography with a publication date prior to 1990, were excluded.
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