Optimización de la dosificación de fármacos en el paciente crítico con hiperfiltración glomerular.
DOI:
https://doi.org/10.30445/rear.v14i2.980Palabras clave:
hiperfiltración glomerular, paciente critico, aumento de aclaramiento renalResumen
La hiperfiltración glomerular es un fenómeno definido por aclaramiento de creatinina superior a 130 ml/min/1.72 m2. Se ha descrito un rango muy amplio de incidencia en el paciente crítico. El uso de dosis convencionales de fármacos de eliminación renal en pacientes con hiperfiltración glomerular puede provocar el fracaso de la terapia, con peor resultado del paciente y aumento de costes. El propósito de esta revisión es proporcionar un resumen actualizado de la evidencia actual sobre hiperfiltración glomerular en el paciente crítico. Para la elaboración de este documento se ha llevado a cabo una revisión no sistemática de artículos indexados en MEDLINE (PubMed) de los últimos veinte años, fecha de actualización diciembre 2019, utilizando las palabras clave “augmented renal clearance”, “critically ill”, “glomerular hyperfiltration”, “hyperfiltration” y “creatinine clearance”.
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