Reversión del Bloqueo Neuromuscular Profundo Inducido por Altas Dosis de Rocuronio mediante Sugammadex en Dos Momentos Diferentes
Pühringer FK, Rex C, Sielenkämper AW, Claudius C, Larsen PB, Prins ME, Eikermann M, Khuenl-Brady KS. Reversal of Profound, High-dose Rocuronium-induced Neuromuscular Blockade by Sugammadex at Two Different Time Points. Anesthesiology 2008; 109: 188-97
DOI:
https://doi.org/10.30445/rear.v1i10.587Keywords:
Anestesia general, bibliografía, relajantes neuromusculares, sugammadexAbstract
El Sugammadex es una gamma-ciclodextrina modificada, diseñada específicamente para unirse selectivamente a los Relajantes NeuroMusculares (RNM) esteroideos, con especial afinidad para el Rocuronio. La interacción Sugammadex-Rocuronio, reduce la cantidad de Rocuronio libre en plasma y en la unión neuromuscular, revirtiendo rápidamente el bloqueo. El Sugammadex abre nuevas perspectivas en el uso clínico del Rocuronio, incluyendo la posibilidad de reversión inmediata del bloqueo producido tras una dosis elevada de Rocuronio.
References
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4. Sparr HJ, Vermeyen KM, Beaufort AM, et al. Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: Efficacy, safety, and pharmacokinetics. Anesthesiology 2007; 106: 935-43.
5. de Kam PJ, van Kuijk J, Smeets J, Thomsen T, Peeters P. Single IV sugammadex doses up to 32 mg/kg are not associated with QT/QTc prolongations. Anesthesiology 2007; 107: A898.
2. Lee C. Goodbye Suxamethonium!. Anaesthesia, 2009, 64 (Suppl. 1): 73-81.
3. Caldwell JE, Miller RD. Clinical implications of Sugammadex. Anaesthesia 2009; 64 Suppl. 1: 66-72.
4. Sparr HJ, Vermeyen KM, Beaufort AM, et al. Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: Efficacy, safety, and pharmacokinetics. Anesthesiology 2007; 106: 935-43.
5. de Kam PJ, van Kuijk J, Smeets J, Thomsen T, Peeters P. Single IV sugammadex doses up to 32 mg/kg are not associated with QT/QTc prolongations. Anesthesiology 2007; 107: A898.
Published
2009-10-31
How to Cite
Planas Roca, A. (2009). Reversión del Bloqueo Neuromuscular Profundo Inducido por Altas Dosis de Rocuronio mediante Sugammadex en Dos Momentos Diferentes: Pühringer FK, Rex C, Sielenkämper AW, Claudius C, Larsen PB, Prins ME, Eikermann M, Khuenl-Brady KS. Reversal of Profound, High-dose Rocuronium-induced Neuromuscular Blockade by Sugammadex at Two Different Time Points. Anesthesiology 2008; 109: 188-97. Revista Electrónica AnestesiaR, 1(10), 3. https://doi.org/10.30445/rear.v1i10.587
Issue
Section
Critical reviews of articles
Revista Electrónica AnestesiaR by 