Utilidad terapéutica de la administración de sangre ozonizada en pacientes con neumonía por COVID-19
DOI:
https://doi.org/10.30445/rear.v13i7.943Palabras clave:
Ozono, COVID-19Resumen
El uso de la ozonoterapia crea controversia. Hasta hace unos años fue considerada una pseudociencia, sin embargo a día de hoy pese a ser una gran desconocida sus acciones terapéuticas son muy remarcables. Al fin y al cabo funciona similar a una cámara hiperbárica pues lo que se administra es oxígeno por ejemplo de manera endovenosa lo que causa en el organismo una respuesta muy beneficiosa. En la Pandemia por COVID-19 aún no hay tratamiento curativo, sin embargo la terapia con ozono parece ser muy beneficiosa, los primeros artículos han sido publicados y los resultados son esperanzadores. Creemos que dado el beneficio de esta terapia debemos profundizar más en su conocimiento para poder servirnos de los beneplácitos que proprociona. Aquí hacemos una revisión de sus efectos beneficiosos con justificación científica.
Citas
-Wu XN, Zhang T, Wang J, Liu X, Li Z, Xiang W, et al. Magnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction. Neural Regen Res. 2016; 11(7): 1115–1121.
-Wu X, Li Z, Liu X, et al. Major ozonated autohemotherapy promotes the recovery of upper limb motor function in patients with acute cerebral infarction. Neural Regen Res. 2013;8(5):461-468.
- Clavo B, Catalá L, Pérez JL, Aguilar Y, Rodríguez V, Robaina F. Ozone Therapy on Cerebral Blood Flow: A Preliminary Report. Evid Based Complement Alternat Med 1, 315-319 (2004).
- Clavo B, Suarez G, Aguilar Y, Gutiérrez D, Ponce P, Cubero A, et al. Brain ischemia and hypometabolism treated by ozone therapy. Forsch Komplementmed 18, 283-287 (2011).
- Pandolfi S, Zammitti A, Franzini M, et al. Effects of oxygen ozone therapy on cardiac function in a patient with a prior myocardial infarction. Ozone Therapy, (2017) 2(1).
- Giunta R, Coppola A, Luongo C, Guastafierro S, Grassia A, Giunta L, et al. Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease. Ann Hematol. 2001;80:745–748
- Andikyan VM, Voloshchuk IN, Kovganko PA, Clemente JM. Morphofunctional changes in the placenta after ozone therapy Bull Exp Biol Med. 2000 Jul;130(7):715–8.
- Mandzhgaladze NR, Kharebava ER, Didia TG, Ardzhevanishvili MD, Gudzhabidze MV, Chigiashvili TN. Influence of intravenous ozone treatment on the level of different specificity antibodies. Georgian Med News. 2006;(138):93-95.
- Thorpe JA, Hollonbeck SA, Viglione DD, et al. Novel therapy for COVID-19 does intravenous ozonated-saline affect blood and tissue oxygenation? J Gynecol Res Obstet 6(2): 046-050.
- Díaz A., García M., Pina C., Menéndez S. Efecto del ozono sobre la actividad plaquetaria en paciente diabéticos tratados con ozonoterapia: informe preliminar. Rev Cubana Invest Biomed. 2001;20(1):45-7
- Schulz S, Ninke S, Watzer B, Nusing RM. Ozone induces synthesis of systemic prostacyclin by cyclooxygenase-2 dependent mechanism in vivo. Biochem Pharmacol 2012;83:506–513.
- Biedunkiewicz B, Lizakowski S, Tylicki L et al. Blood coagulation unaffected by ozonated autohemotherapy in patients on maintenance hemodialysis. Arch Med Res. 2006;37(8):1034‐1037.
- Martínez Y, Zamora Z, González R ,et al. Effect of ozone oxidative preconditioning on bleeding time and venous thrombosis in a septic shock model in rats. Ciencias Biológicas. 2010;41. ISSN: 0253-5688.
- Yu G, Bai Z, Chen Z, Chen H, Wang G, Wang G, et al. The NLRP3 inflammasome is a potential target of ozone therapy aiming to ease chronic renal inflammation in chronic kidney disease. Int Immunopharmacol 2017;43:203-9. doi: 10.1016/j.intimp.2016.12.022.
- Tartari, A.P.S., Moreira, F.F., Pereira, M.C.D.S. et al. Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis. Inflammation (2020). https://doi.org/10.1007/s10753-020-01184-2.
- Chen, H, Lu C, Lin Q. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. Rheumatol Int 33, 1223–1227 (2013). https://doi.org/10.1007/s00296-012-2529-7
- Bin Y, Chen H, Lu C, Lin Q, Wang B, Qin C. Effect of Intra-Articular Ozone Injection on Serum and Synovial TNF-α, TNFR I, and TNFR II Contents in Rats With Rheumatoid Arthritis. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(6):1055-8.
- Delgado-Roche L, Riera Romo M, Mesta F, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients. Eur J Pharmacol. 2017;811:148‐154. doi:10.1016/j.ejphar.2017.06.017
- Ameli J, Banki A, Khorvash F, Simonetti V, Jafari NJ, Izadi M. Mechanisms of pathophysiology of blood vessels in patients with multiple sclerosis treated with ozone therapy: a systematic review. Acta Biomed. 2019;90(3):213‐217. Published 2019 Sep 6. doi:10.23750/abm.v90i3.7265
- Sancak EB, Turkon H, Cukur S et al: Major ozonated autohemotherapy pre-conditioning ameliorates kidney ischemia-reperfusion injury. Inflammation, 2016; 39(1): 209–17 11.
- Foglieni C, Fulgenzi A, Belloni D,Erimsah S, Akbas A, Gulpinar MT, et al: Ozonated autohemotherapy: Protection of kidneys from ischemia in rats subjected to unilateral nephrectomy. BMC Nephrol, 2011; 12: 61
- WHO. Disinfectants and Disinfection By-Products. Disponible en: https://www.who.int/water sanitation health/dwq/S04.pdf.
- Sagai M, Bocci V: Mechanisms of action involved in ozone therapy: Is heal-ing induced via a mild oxidative stress? Med Gas Res, 2011; 1: 29
- Hernandez A, Papadakos PJ, Torres A, González DA, Vives M, Ferrando C, et al. Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. Rev Esp Anestesiol Reanim 2020:67: 245-252. (HTML)
Hernández A, Viñals M, Isidoro T, Vilas F. Potential Role of Oxygen–Ozone Therapy in Treatment of COVID-19 Pneumonia. Am J Case Rep 21: e925849.
- Hernández A., Vinals M., Pablos A., Vilas F, Ppadakos P, Wijeysundera D, et al. Ozone therapy for patients with SARS-COV-2 pneumonia: a single-center prospective cohort study. MedRxiv. 2020 doi: 10.1101/2020.06.03.20117994.
- Menendez S, Marques de Magallanes JA, Hernandez A, HidalgoF, Baeza J. Therapeutic Effects of Ozone Therapy that Justifies its Use for the Treatment of COVID-19. J Neurol Neurocrit Care, Volume3(1): 1–6, 202
- Franzini M, Valdenassi L, Recevuti G, Chirumbolo S, Depfenhart M, Bertossi , et al. Oxygen-ozone (O2-O3) immunoceutical therapy for patients with COVID-19. Preliminary evidence reported. Int Immunopharmacol. 2020 Nov; 88: 106879. doi.org/10.1016/j.intimp.2020.106879
- Zheng, Zhishui et al. “A preliminary evaluation on the efficacy of ozone therapy in the treatment of COVID-19.” Journal of medical virology, 10.1002/jmv.26040. 21 May. 2020, doi:10.1002/jmv.26040
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2021 Revista Electrónica AnestesiaR
Esta obra está bajo una licencia internacional Creative Commons Atribución-CompartirIgual 4.0.
Envío y derechos de autor
Revista Electrónica AnestesiaR by 