Eficacia del Sugammadex en anestesia con Sevofluorane o Propofol
Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia. Rex C, Wagner S, Spies C, Scholz J, Rietbergen H, Heeringa M, Wulf H. Anesthesiology. 2009 Jul;111(1):30-5.
DOI:
https://doi.org/10.30445/rear.v2i1.492Palabras clave:
Anestesia general, Farmacología, Novedades farmacológicas, Propofol, ReAR, Sevoflurano, sugammadexResumen
Todos los estudios previos con Sugammadex han sido realizados con bolos únicos o repetidos de bloqueantes neuromusculares (NMBA). Ningún estudio, salvo en monos Rhesus, ha empleado una dosis única de Sugammadex para revertir el bloqueo neuromuscular residual en pacientes quirúrgicos tras una INFUSIÓN CONTINUA de ROCURONIO, que supone mayor tiempo de recuperación de la altura de T1 comparado con el empleo de bolos repetidos de este relajante. El mantenimiento de la anestesia con agentes volátiles halogenados como el SEVOFLUORANE potencia el efecto de bloqueo neuromuscular de los relajantes, en comparación con la anestesia basada en PROPOFOL en perfusión. Esta potenciación se hace más patente en caso de infusión continua de relajante.
Citas
1. Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium Sparr HJ, Booij LH, Fuchs-Buder T. Anaesthesist. 2009 Jan;58(1):66-80. Review.
2. Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block. Shields M, Giovannelli M, Mirakhur RK, Moppett I, Adams J, Hermens Y. Br J Anaesth. 2006 Jan;96(1):36-43.
3. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. de Boer HD, van Egmond J, van de Pol F, Bom A, Booij LH. Anesthesiology. 2006 Apr;104(4):718-23.
4. Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium. Berg H, Roed J, Viby-Mogensen J, Mortensen CR, Engbaek J, Skovgaard LT, Krintel JJ. Acta Anaesthesiol Scand. 1997 Oct;41(9):1095-1103.
5. Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study. Sorgenfrei IF, Norrild K, Larsen PB, Stensballe J, Ostergaard D, Prins ME, Viby-Mogensen J. Anesthesiology. 2006 Apr;104(4):667-74.
2. Org 25969 (sugammadex), a selective relaxant binding agent for antagonism of prolonged rocuronium-induced neuromuscular block. Shields M, Giovannelli M, Mirakhur RK, Moppett I, Adams J, Hermens Y. Br J Anaesth. 2006 Jan;96(1):36-43.
3. Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. de Boer HD, van Egmond J, van de Pol F, Bom A, Booij LH. Anesthesiology. 2006 Apr;104(4):718-23.
4. Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium. Berg H, Roed J, Viby-Mogensen J, Mortensen CR, Engbaek J, Skovgaard LT, Krintel JJ. Acta Anaesthesiol Scand. 1997 Oct;41(9):1095-1103.
5. Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study. Sorgenfrei IF, Norrild K, Larsen PB, Stensballe J, Ostergaard D, Prins ME, Viby-Mogensen J. Anesthesiology. 2006 Apr;104(4):667-74.
Publicado
2010-01-31
Cómo citar
Serrano Díaz, Ángel. (2010). Eficacia del Sugammadex en anestesia con Sevofluorane o Propofol: Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia. Rex C, Wagner S, Spies C, Scholz J, Rietbergen H, Heeringa M, Wulf H. Anesthesiology. 2009 Jul;111(1):30-5. Revista Electrónica AnestesiaR, 2(1), 2. https://doi.org/10.30445/rear.v2i1.492
Número
Sección
Comentarios de artículos
Revista Electrónica AnestesiaR by 