Calabadion, el nuevo Reversor Muscular

  • Robert Blasco Mariño Residente de Anestesiología y Reanimación. Hospital Universitario Vall d’Hebron de Barcelona.
  • Anna Abad Torrent Vicepresidenta de GATIV. Servicio de Anestesiología y Reanimación. Hospital Universitario Vall d’Hebron de Barcelona.

Resumen

Todavía no comercializado, Calabadion 2; un nuevo reversor de los bloqueantes neuromusculares. Se une al rocuronio con una afinidad 89 veces mayor que el Sugammadex.

Citas

1. Haerter F, Eikermann M. Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion. Expert Opin Pharmacother. 2016;17(6):819-33.
2. Macartney DH. Cucurbit[n]uril type hosts for the reversal of steroidal neuromuscular blocking agents. Future Med Chem. 2013 Nov;5(17):2075-89.
3. Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I et al. A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2. Anesthesiology. 2016 Aug;125(2):333-45.
4. Ganapati S, Zavalij PY, Eikermann M, Isaacs L. In Vitro selectivity of an acyclic cucurbit[n]uril molecular container towards neuromuscular blocking agents relative to commonly used drugs. Org Biomol Chem. 2016 Jan 28;14(4):1277-87
5. Hoffmann U, Grosse-Sundrup M, Eikermann-Haerter K, Zaremba S, Ayata C, Zhang B, Ma D, Isaacs L, Eikermann M. Calabadion: A new agent to reverse the effects of benzylisoquinoline and steroidal neuromuscular-blocking agents. Anesthesiology. 2013 Aug;119(2):317-25.
Publicado
22-05-2017
##submission.howToCite##
BLASCO MARIÑO, Robert; ABAD TORRENT, Anna. Calabadion, el nuevo Reversor Muscular. Revista Electrónica AnestesiaR, [S.l.], v. 9, n. 12, p. 3, mayo 2017. ISSN 1989-4090. Disponible en: <http://revistaanestesiar.org/index.php/rear/article/view/602>. Fecha de acceso: 23 ene. 2018

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